- Title
- An Alternative Method for Synthesizing N,2,3-Trimethyl-2H-indazol-6-amine as a Key Component in the Preparation of Pazopanib
- Creator
- Bui, Thi Thanh Cham; Luu, Hue Linh; Luong, Thi Thanh; Nguyen, Thi Ngoc; Dao, Nguyet Suong Huyen; Nguyen, Van Giang; Nguyen, Dinh Luyen; Trinh, Nguyen Trieu; Nguyen, Van Hai
- Relation
- Chemistry Vol. 6, Issue 5, p. 1089-1098
- Publisher Link
- http://dx.doi.org/10.3390/chemistry6050063
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2024
- Description
- Due to its application as an anti-cancer drug, pazopanib (1) has attracted the interest of many researchers, and several studies on pazopanib synthesis have been reported over the years. This paper provides a novel route for synthesizing N,2,3-trimethyl-2H-indazol-6-amine (5), which is a crucial building block in the synthesis of pazopanib from 3-methyl-6-nitro-1H-indazole (6). By alternating between the reduction and two methylation steps, compound 5 was obtained in a yield comparable (55%) to what has been reported (54%). It is noteworthy that the last step of N2-methylation also yielded N,N,2,3-tetramethyl-2H-indazol-6-amine (5′) as a novel compound. Furthermore, the data presented in this paper can serve as a valuable resource for future research aimed at further refining the process of synthesizing pazopanib and its derivatives.
- Subject
- 3-methyl-6-nitro-1H-indazole; pazopanib; N,N,2,3-tetramethyl-2H-indazol-6-amine; N,2,3- trimethyl-2H-indazol-6-amine; SDG 3; Sustainable Development Goal
- Identifier
- http://hdl.handle.net/1959.13/1517321
- Identifier
- uon:57068
- Identifier
- ISSN:2624-8549
- Rights
- x
- Language
- eng
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